Multiple Sclerosis (MS) is a chronic neurological disorder affecting the central nervous system, often causing symptoms like muscle weakness, coordination issues, and cognitive difficulties. Fatigue, one of the most common and disabling symptoms, impacts up to 80% of MS patients, severely affecting daily life and overall well-being. Modafinil, a wake-promoting agent, has been explored as…

Post-stroke fatigue (PSF) is a persistent and debilitating condition that affects up to 70% of stroke survivors, often lasting months or even years (Bivard et al., 2017; Cross et al., 2020). Unlike normal tiredness, PSF interferes significantly with quality of life, limiting independence and rehabilitation outcomes. Despite its prevalence, effective pharmacological treatments have been limited—until…

Sunosi (solriamfetol) and Modafinil are both FDA-approved medications used to treat excessive daytime sleepiness (EDS) associated with narcolepsy and obstructive sleep apnea (OSA). While they share a goal—to improve wakefulness—their mechanisms of action, clinical effectiveness, side effect profiles, and cost structures differ in ways that may influence treatment decisions. Key Takeaways What Is Sunosi (Solriamfetol)?…

Restless Leg Syndrome (RLS) is marked by an uncontrollable urge to move the legs, often triggered by uncomfortable sensations that occur during the evening or nighttime while sitting or lying down. Modafinil, primarily used to treat narcolepsy, has been investigated for its potential to relieve RLS symptoms. Insights from a patent on modafinil’s use for…

Modafinil, initially prescribed for narcolepsy and other sleep disorders, has gained popularity as a cognitive enhancer. Its effects on dopamine levels are particularly significant, as dopamine is key to cognitive function and motivation. Exploring how Modafinil influences dopamine provides insight into its impact on cognitive performance and mental clarity. Modafinil and Its Uses Medical Uses…

Modafinil, widely recognized for its wakefulness-promoting effects, was originally developed to treat conditions such as narcolepsy, shift work sleep disorder, and obstructive sleep apnea. It has since gained popularity for off-label uses like cognitive enhancement and improved focus, particularly among students and professionals. However, its rising use has raised concerns about potential health risks, including…

What is Modafinil? Modafinil (brand name Provigil®) is a prescription medication primarily used to promote wakefulness in individuals with sleep disorders, such as narcolepsy, shift work sleep disorder, and obstructive sleep apnea (FDA, 2007).Beyond its approved uses, modafinil has seen growing off-label adoption as a cognitive enhancer among healthy individuals (Kumar, 2008; Porsdam-Mann & Sahakian,…

Chronic Fatigue Syndrome (CFS), or Myalgic Encephalomyelitis (ME), is a long-term condition characterized by persistent fatigue that is not relieved by rest. Standard therapies such as cognitive behavioral therapy (CBT) and graded exercise therapy (GET) have limited effectiveness for many patients. Modafinil, a medication approved to treat excessive daytime sleepiness in narcolepsy, is increasingly considered…