Modafinil Interactions with Common Medications, Foods, and Supplements
Modafinil is a wakefulness-promoting agent approved by the FDA for the treatment of narcolepsy, obstructive sleep apnea (OSA), and shift work disorder (FDA, 2015). It is also used off-label for cognitive enhancement and fatigue reduction. While generally well-tolerated, modafinil interacts with various medications, supplements, and physiological systems through its modulation of hepatic enzymes. Understanding these…