Modafinil is a prescription medication originally developed to treat narcolepsy, but it has also been used by professionals, students, and the military for its wakefulness-promoting and cognitive-enhancing effects. While it is not a stimulant in the same class as amphetamines, users often describe increased focus, productivity, and alertness. At the same time, potential side effects…
Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), affects millions worldwide. Many people experience persistent fatigue, brain fog, and neurocognitive difficulties that can last months after the initial infection. Because no standardized treatment exists, researchers and clinicians are exploring whether existing medications—such as modafinil, a wakefulness-promoting agent—might offer relief. Key Takeaways Understanding…
Excessive daytime sleepiness (EDS) can leave individuals feeling persistently drowsy and struggling to stay alert, even after a full night’s rest. This condition can significantly impair daily functioning, productivity, and safety. Modafinil, a wakefulness-promoting agent, has become a widely used treatment for EDS associated with disorders such as narcolepsy, obstructive sleep apnea (OSA), and shift…
Modafinil and its related compound, armodafinil, are wakefulness-promoting agents prescribed for conditions such as narcolepsy, shift work sleep disorder, and obstructive sleep apnea. While they can be effective for treating excessive sleepiness, reports of serious side effects—including conjunctivitis and mouth ulcers—highlight the risks of unsupervised use. Key Takeaways What Is Modafinil? Modafinil is a non-amphetamine…
Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS), affecting up to 78% of patients and often reducing quality of life and work capacity (Oliva Ramirez et al., 2021). Unlike ordinary tiredness, MS-related fatigue can appear suddenly, persist throughout the day, and is not always relieved by rest. Given the…
Post-stroke fatigue (PSF) is a persistent and debilitating condition that affects up to 70% of stroke survivors, often lasting months or even years (Bivard et al., 2017; Cross et al., 2020). Unlike normal tiredness, PSF significantly disrupts quality of life, limiting independence and slowing rehabilitation progress. Despite its prevalence, effective pharmacological treatments have been limited…
Sunosi (solriamfetol) and Modafinil are both FDA-approved medications used to treat excessive daytime sleepiness (EDS) associated with narcolepsy and obstructive sleep apnea (OSA). While they share a goal—to improve wakefulness—their mechanisms of action, clinical effectiveness, side effect profiles, and cost structures differ in ways that may influence treatment decisions. Key Takeaways What Is Sunosi (Solriamfetol)?…
Restless Legs Syndrome (RLS) is a common neurological disorder marked by an uncontrollable urge to move the legs, usually accompanied by unpleasant sensations that worsen at night. While several effective therapies exist, some researchers have explored whether modafinil, a wakefulness-promoting medication, could help. Key Takeaways Understanding Restless Legs Syndrome RLS, also known as Willis–Ekbom disease,…